Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, material and methods related to the treatment of hypertrophic cardiomyopathy are provided.
申请公布号
WO2005027625(A3)
申请公布日期
2005.10.27
申请号
WO2004US30728
申请日期
2004.09.17
申请人
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;SPELSBERG, THOMAS, C.;SUBRAMANIAM, MALAYANNAN;OURSLER, MERRY, JO;RAJAMANNAN, NALINI, M.
发明人
SPELSBERG, THOMAS, C.;SUBRAMANIAM, MALAYANNAN;OURSLER, MERRY, JO;RAJAMANNAN, NALINI, M.