METHODS AND COMPOSITIONS FOR THE TREATMENT OF HELICOBACTER PYLORI-ASSOCIATED DISEASES USING ENDOPEROXIDE BRIDGE-CONTAINING COMPOUNDS

摘要

The present invention relates to methods and compositions for treating pathological conditions associated with ferrous-dependent bacteria, such as, Helicobacter pylori in which high intracellular ferrous iron concentration is required for their survival and pathogenesis. The compositions of the invention comprise endoperoxide bridge-containing compounds that specifically inhibit the growth of the ferrous-dependent bacteria and preferably promote the eradication of the bacteria. The compositions, typically also include at least one active agents for treating Helicobacter sp -related gastrointestinal disorders, such as a proton pump inhibitor, an H2 blocker or a bismuth-containing compound.