发明名称 |
COMBINATION OF (S)-AMLODIPINE AND A BETA-BLOCKER, AND METHODS FOR REDUCING HYPERTENSION |
摘要 |
<p>One aspect of the present invention relates to pharmaceutical compositions comprising optically pure (S)-amlodipine and a beta-blocker. In a preferred embodiment, the beta-blocker is atenolol or bisprolol. Another aspect of the present invention relates to pharmaceutical compositions consisting essentially of at least one pharmaceutically acceptable carrier, optically pure (S)-amlodipine and a beta-blocker. In a preferred embodiment, the beta-blocker is atenolol or bisoprolol. The pharmaceutical compositions of the invention are useful, e.g., in the treatment of hypertension. In addition, the present invention also relates to a method of treating a patient suffering from hypertension or a related cardiac disorder, comprising co-administering to a patient in need thereof a therapeutically effective amount of optically pure (S)-amlodipine and a beta-blocker. In certain embodiments of the compositions and methods, said optically pure (S)-amlodipine is optically pure (S)-amlodipine malate, or a polymorph, pseudopolymorph or solvate thereof.</p> |
申请公布号 |
WO2005099699(A1) |
申请公布日期 |
2005.10.27 |
申请号 |
WO2005US10485 |
申请日期 |
2005.03.29 |
申请人 |
SEPRACOR INC.;BUSH, LARRY;GROGAN, DONNA, ROY |
发明人 |
BUSH, LARRY;GROGAN, DONNA, ROY |
分类号 |
A61K31/44;(IPC1-7):A61K31/44;A61P9/00 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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