发明名称 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
摘要 |
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
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申请公布号 |
US2005239725(A1) |
申请公布日期 |
2005.10.27 |
申请号 |
US20050158405 |
申请日期 |
2005.06.21 |
申请人 |
XENOPORT, INC. |
发明人 |
GALLOP MARK A.;XIANG JIA-NING;YAO FENMEI;BHAT LAXMINARAYAN;ZHOU CINDY X. |
分类号 |
C07C271/12;C07C271/22;C07F9/40;(IPC1-7):A61K31/704;A61K31/496;A61K31/445;A61K31/325 |
主分类号 |
C07C271/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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