| 发明名称 |
PROCESS FOR THE PREPARATION OF (E)-5-(2-BROMOVINYL)-2'DEOXYURIDINE |
| 摘要 |
The present invention relates to the preparation of (E)-5-(2-bromovynyl)-2'-deoxyuridine (Brivudine) characterized in that halogen-free solvents selected form esters or cyclic ethers are used in the bromination step of 5-ethyl-2'-deoxyuridine diacylate. The use of said solvents is advantageous in respect of toxicity, discharge costs and environment protection.
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| 申请公布号 |
EA006156(B1) |
申请公布日期 |
2005.10.27 |
| 申请号 |
EA20030000761 |
申请日期 |
2002.02.21 |
| 申请人 |
MENARINI RICERCHE S.P.A.;BERLIN-CHEMIE AG |
发明人 |
SALIMBENI, ALDO;MAGGI, CARLO, ALBERTO;MANZINI, STEFANO;TUROZZI, DAMIANO |
| 分类号 |
C07H19/073;C07B61/00;C07H19/06;(IPC1-7):C07H19/06 |
主分类号 |
C07H19/073 |
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