发明名称 MASS SPECTROMETRY OF ANTIBODY CONJUGATES
摘要 <p num="1"><br/><br/><br/>Methods to detect, screen, and quantitate biological samples after <br/>administration of antibody conjugates, antibody-drug conjugates of Formula <br/>(I), antibodies, and fragments and metabolites thereof, by affinity <br/>separation, chromatography, and mass spectrometry are disclosed. Ab-(L-D)p (I) <br/>wherein Ab is an antibody; D is a drug moiety; L is a linker covalently <br/>attached to Ab, and covalently attached to D; and p is 1, 2, 3, 4, 5, 6, 7, or <br/>8.<br/>
申请公布号 CA2559870(A1) 申请公布日期 2005.10.27
申请号 CA20052559870 申请日期 2005.04.06
申请人 GENETECH, INC. 发明人 MANN, EMILY;KADKHODAYAN, MIRYAM
分类号 G01N33/68;A61K39/395;C07K16/28;C07K16/32;C07K16/46;C12P21/06;C12P21/08;G01N33/53 主分类号 G01N33/68
代理机构 代理人
主权项
地址