发明名称 |
IMMORTALIZED NATURAL KILLER CELL LINE |
摘要 |
<p>The present invention provides an immortalized natural killer cell line retaining the function and characteristics intrinsic to natural killer cells, a method for establishing the same, a method for screening for useful substances using the immortalized natural killer cell line, and a cell vaccine. By culturing natural killer cells obtained by isolating natural killer cells from the spleen of a transgenic mouse to which a large T-antigen gene of SV40 temperature-sensitive mutant tsA58 is introduced, a cell line which proliferates and activates in the presence of Interleukin-2, has azurophilic granules within cytoplasm, and retains an ability to kill a target cell without presensitization and/or an ability to kill target cells coated with an antibody, is established. <IMAGE></p> |
申请公布号 |
EP1589099(A1) |
申请公布日期 |
2005.10.26 |
申请号 |
EP20030770043 |
申请日期 |
2003.10.30 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
IIZUKA, SATORU;TAKAI, TOSHIYUKI;ITO, YUMI;ITO, KOZUE;OGINATA, MASUO |
分类号 |
A01K67/027;C12N15/09;A61K35/28;A61K39/00;A61P31/04;A61P31/12;A61P35/00;C12N5/0783;C12N5/10;C12Q1/02;G01N33/50;(IPC1-7):C12N5/10;A61K45/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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