| 发明名称 |
SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS |
| 摘要 |
<p>This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR<SUP>5</SUP>, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.</p> |
| 申请公布号 |
EP1289965(B1) |
申请公布日期 |
2005.10.26 |
| 申请号 |
EP20010980030 |
申请日期 |
2001.05.16 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
DVORAK, CHARLES, ALOIS;FISHER, LAWRENCE, EMERSON;GREEN, KEENA, LYNN;HARRIS, RALPH, NEW, III;MAAG, HANS;PRINCE, ANTHONY;REPKE, DAVID, BRUCE;STABLER, RUSSELL, STEPHEN |
| 分类号 |
A61K31/535;A61K31/55;A61K31/551;A61K31/553;A61P1/04;A61P1/06;A61P1/12;A61P3/00;A61P9/00;A61P11/00;A61P11/06;A61P13/00;A61P13/02;A61P13/06;A61P15/00;A61P21/00;A61P21/02;A61P43/00;C07D207/26;C07D207/27;C07D211/76;C07D223/10;C07D225/02;C07D239/10;C07D241/08;C07D243/04;C07D243/08;C07D265/10;C07D267/06;C07D267/10;C07D267/22;C07D279/06;C07D401/06;C07D401/12;C07D403/06;C07D403/12;C07D405/06;C07D405/12;C07D405/14;C07D409/06;C07D409/12;C07D409/14;C07D411/12;C07D413/06;C07D413/12;C07D413/14;C07D417/06;C07D417/12;C07D417/14;C07D487/04;C07D513/04;C07D513/14;(IPC1-7):C07D241/08 |
主分类号 |
A61K31/535 |
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