发明名称 |
STABLE SOLID MEDICINAL COMPOSITION FOR ORAL ADMINISTRATION OF RAMOSETRON |
摘要 |
<p>This invention is aimed to provide a stabilized formulation of ramosetron or a pharmaceutically acceptable salt thereof under a temperature/humidity condition, especially at a low content and relates to a stable oral solid drug composition of ramosetron or a pharmaceutically acceptable salt thereof, which is characterized by containing one or two or more members selected from the group consisting of an aliphatic carboxylic acid or an ester thereof, a hydroxycarboxylic acid or an ester thereof, an acidic amino acid, an enolic acid, an aromatic carboxyl compound or an ester thereof, and a carboxyl group-containing high-molecular substance, and to a stabilization method of the same. Also, this invention relates to a therapeutic agent of diarrhea-predominant irritable bowel syndrome containing from 0.002 to 0.02 mg of ramosetron hydrochloride as a daily dose or an equivalent molar amount of ramosetron or its pharmaceutically acceptable other salt as an active ingredient.</p> |
申请公布号 |
EP1588707(A1) |
申请公布日期 |
2005.10.26 |
申请号 |
EP20040706797 |
申请日期 |
2004.01.30 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
SUGIHARA, A;MASAKI, K.;YASUJI, T.;NISHIDA, A.;NIWA, A.;ATSUTA, Y. |
分类号 |
A61K47/04;A61K9/14;A61K9/20;A61K31/00;A61K31/19;A61K31/4184;A61K47/02;A61K47/12;A61K47/14;A61K47/18;A61K47/22;A61K47/30;A61K47/32;A61K47/36;A61K47/38;A61P1/00;A61P1/12;A61P25/00;A61P43/00;C07D213/61;C07D403/06;(IPC1-7):A61K31/418 |
主分类号 |
A61K47/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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