| 摘要 |
The invention relates to novel peptides, which are biologically active as ligands of the blood platelet integrin GPIIbIIIa and of alphav-integrins, preferably alphav beta6 and alphavbeta3-integrin, of formula (I):R1-Arg-X-Asp-Leu-Asp-Ser-Leu-Arg-R2, wherein: R1 represents H, acetyl or acyl; R2 represents -OH, OR3, NH2, NHR3, N(R3)2; R3 represents alkyl, aralkyl, aryl, het, and; X represents an amino acid of formula (II), wherein: A represents (CH 2)n; R4 represents H, alkyl, aralkyl or aryl, and; n represents 1, 2, 3, 4, 5 or 6. The amino acid of formula (II) is bound via a peptide bond of the alpha-amino group to the adjacent Arg and is bound via a peptide bond of the alpha-carboxyl group to the alpha- amino group of the adjacent Asp.
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