| 发明名称 |
Formulation of boronic acid compounds |
| 摘要 |
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1): in which Z<SUP>1 </SUP>and Z<SUP>2 </SUP>are moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.
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| 申请公布号 |
US6958319(B2) |
申请公布日期 |
2005.10.25 |
| 申请号 |
US20030664732 |
申请日期 |
2003.09.18 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
GUPTA SHANKER LAL |
| 分类号 |
A61K9/19;A61K31/69;A61K38/00;A61K38/14;A61P29/00;A61P31/18;A61P35/00;A61P37/02;A61P43/00;C07F5/02;C07F5/04;C07F5/05;C07H9/00;C07K5/06;C07K5/062;C07K5/065;C07K5/078;C07K5/08;C07K5/083;C07K5/097;C07K5/117;C07K7/02;C07K9/00;(IPC1-7):A61K38/00;A61K33/22 |
主分类号 |
A61K9/19 |
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