发明名称 |
Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof. |
摘要 |
A composition for inducing or potentiating an immune response, preferably a CTL, T helper cell, or neutralizing antibody response in a subject, comprising an antigen and/or a non-antigen bioactive agent capable of inducing or potentiating such an immune response encapsulated in a polymeric composition, wherein the polymeric composition comprises a blend of (a) a polymer present in an amount sufficient to provide structural integrity to the polymeric composition, and (b) a rapidly biodegradable component, a rapidly dissolving component, a rapidly swelling component, or a component that causes osmotic rupture of the encapsulated polymeric composition is disclosed. Single polymer compositions for achieving such an immune response are also disclosed. Methods for inducing or potentiating a CTL, T helper cell or neutralizing antibody response using the above-identified compositions are disclosed. |
申请公布号 |
HK1029742(A1) |
申请公布日期 |
2005.10.21 |
申请号 |
HK20000108319 |
申请日期 |
2000.12.21 |
申请人 |
CORIXA CORPORATION;SOUTHERN RESEARCH INSTITUTE |
发明人 |
STAAS, JAY, K.;TICE, THOMAS, R.;SYAMAL RAYCHAUDHURI;SLEATH, PAUL, R. |
分类号 |
A61K9/00;A61K9/16;A61K39/39;(IPC1-7):A61K |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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