| 发明名称 |
Antibacterial compounds and methods for treating gram positive bacterial infections |
| 摘要 |
The present inventive subject matter relates to novel antibacterial compounds that are capable of inhibiting bacterial multiplication and killing living bacteria. The present inventive subject matter further relates to methods for treating Gram positive bacterial infections using the inventive compounds. <tables id="TABLE-US-00001" num="1"> <table frame="none" colsep="0" rowsep="0"> <tgroup align="left" colsep="0" rowsep="0" cols="1"> <colspec colname="1" colwidth="217PT" align="left"/> <THEAD> <ROW> <ENTRY/> </ROW> <ROW> <entry namest="1" nameend="1" align="center" rowsep="1"/> </ROW> </THEAD> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> </TBODY> </TGROUP> <tgroup align="left" colsep="0" rowsep="0" cols="1"> <colspec colname="1" colwidth="217PT" align="right"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> </TBODY> </TGROUP> <tgroup align="left" colsep="0" rowsep="0" cols="3"> <colspec colname="1" colwidth="14PT" align="left"/> <colspec colname="2" colwidth="119PT" align="left"/> <colspec colname="3" colwidth="84PT" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> <ENTRY>R<SUB>1</SUB></ENTRY> <ENTRY>R<SUB>2</SUB></ENTRY> </ROW> <ROW> <entry namest="1" nameend="3" align="center" rowsep="1"/> </ROW> <ROW> <ENTRY>1</ENTRY> <ENTRY>alpha-D-Mannosyl-(1->2)-alpha-D-mannose</ENTRY> <ENTRY>NH<SUB>3</SUB><SUP>+</SUP></ENTRY> </ROW> <ROW> <ENTRY>2</ENTRY> <ENTRY>H</ENTRY> <ENTRY>NH<SUB>3</SUB><SUP>+</SUP></ENTRY> </ROW> <ROW> <ENTRY>3</ENTRY> <ENTRY>alpha-D-Mannosyl-(1->2)-alpha-D-mannose</ENTRY> <ENTRY>HNC(NH)NH<SUB>3</SUB><SUP>+</SUP></ENTRY> </ROW> <ROW> <ENTRY>4</ENTRY> <ENTRY>alpha-D-Mannosyl-(1->2)-alpha-D-mannose</ENTRY> <ENTRY>HN<SUP>+</SUP>(CH<SUB>2</SUB>)<SUB>2</SUB>CH(CH<SUB>3</SUB>)<SUB>2</SUB></ENTRY> </ROW> <ROW> <ENTRY>5</ENTRY> <ENTRY>alpha-D-Mannosyl-(1->2)-alpha-D-mannose</ENTRY> <ENTRY>NHAc</ENTRY> </ROW> <ROW> <ENTRY>6</ENTRY> <ENTRY>alpha-D-Mannosyl-(1->2)-alpha-D-mannose</ENTRY> <ENTRY>NH<SUB>3</SUB><SUP>+</SUP> (Lactone hydrolyzed)</ENTRY> </ROW> <ROW> <entry namest="1" nameend="3" align="center" rowsep="1"/> </ROW> </TBODY> </TGROUP> </TABLE> </TABLES>
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| 申请公布号 |
US2005233971(A1) |
申请公布日期 |
2005.10.20 |
| 申请号 |
US20040516012 |
申请日期 |
2004.11.29 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSLYVANIA |
发明人 |
MCCAFFERTY DEWEY G. |
| 分类号 |
A61K38/00;A61K38/08;C07K7/06;(IPC1-7):A61K38/08 |
主分类号 |
A61K38/00 |
| 代理机构 |
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| 地址 |
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