5-HT2B RECEPTOR ANTAGONISTS

摘要

The use of a compound of formula: (Ia); or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of increased visceral sensitivity or visceral pain, wherein: one of R<1> and R<4> is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R<1> and R<4> is an optionally substituted C9-14 aryl group; R<2> and R<3> are either: (i) independently selected from H, R, R', SO2R, C(=O)R, (CH2)nNR<5>R<6>, where n is from 1 to 4 and R<5> and R<6> are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group.