发明名称 |
Anti-idiotype anti-CEA antibody molecules and its use as cancer vaccine. |
摘要 |
The present invention provides molecules, preferably designed immunoglubulins, suitable for use as an anti-idiotype vaccine to CEA positive tumours. The molecules induce both an MHC class I and MHC class II mediated immune response to the CEA bearing tumour cells for an efficient and sustained host anti-tumour response. The present invention provides modified versions of anti-idiotype anti-CEA antibodies, preferably mouse antibody 708, with improved vaccination properties. The modifications are related to the introduction of sequences tracts deriving from e.g. CEA, CD 55 antigen and CEA cancer-specific MHC epitopes into the variable regions of said antibody molecules. |
申请公布号 |
ZA200409034(B) |
申请公布日期 |
2005.10.20 |
申请号 |
ZA20040009034 |
申请日期 |
2004.11.08 |
申请人 |
MERCK PATENT GMBH. |
发明人 |
GRAHAM CARTER;CARR, FRANCIS, J. |
分类号 |
C12N15/09;A61K38/00;A61K39/00;A61K39/395;A61P35/00;C07K16/08;C07K16/28;C07K16/30;C07K16/42;C07K16/46;C07K19/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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