发明名称 |
Method of treating solid tumors and leukemias using combination therapy of vitamin D and anti-metabolic nucleoside analogs |
摘要 |
The present invention relates to a method of inhibiting solid tumor cell or leukemia cell proliferation by first administering to a solid tumor cell or leukemia cell either vitamin D or a derivative thereof and subsequently administering at least one anti-metabolic nucleoside analog to the solid tumor cell or the leukemia cell. Also disclosed is a method of treating a cancerous condition. Methods of down regulating a p-AKt survival signaling pathway and modulating activity of a pro-apoptotic caspases is also disclosed.
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申请公布号 |
US2005234009(A1) |
申请公布日期 |
2005.10.20 |
申请号 |
US20050093123 |
申请日期 |
2005.03.29 |
申请人 |
JOHNSON CANDACE S;TRUMP DONALD L |
发明人 |
JOHNSON CANDACE S.;TRUMP DONALD L. |
分类号 |
A61K31/59;A61K31/7072;A61K31/7076;(IPC1-7):A61K31/707;A61K31/707 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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