摘要 |
The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R5, R6, Q and Y are as defined in the specification. The present invention also relates to a process for preparing such compounds, compositions containing such compounds, and use of such compound and composition in medicine. The compounds of the general formula (I) induce HSP-70 and are useful for the treatment of diseases accompanying pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, diseases of viral origin, allograft rejection, tumourous diseases, gastric mucosal damage, brain haemorrhage, endothelial dysfunctions, diabetic complications, neuro-degenerative diseases, post-traumatic neuronal damage, acute renal failure, glaucoma and aging related skin degeneration. |
申请人 |
TORRENT PHARMACEUTICALS LTD;KUMAR, PRABHAT;MANE, UTTAM, RAJARAM;GUPTA, RAMESH, CHANDRA;NADKARNI, SUNIL, SADANAND;MOHANAN, ANOOKH;TANDON, RUCHI;MUNSHI, SIRALEE |
发明人 |
KUMAR, PRABHAT;MANE, UTTAM, RAJARAM;GUPTA, RAMESH, CHANDRA;NADKARNI, SUNIL, SADANAND;MOHANAN, ANOOKH;TANDON, RUCHI;MUNSHI, SIRALEE |