发明名称 |
Low molecular weight heparin salt with triethanolamine useful as therapeutic-antitrombotic agent of local delivery, procedures for preparing them, process for elimination of hygroscopicity of heparin salt, pharmaceutical compositions for local use in antithrombotic therapy and uses therein |
摘要 |
Low molecular weight heparin salt with triethanolamine useful as a therapeutic-antithrombotic agent for local delivery, having at least 60% of its total mass a molecular weight of less than 8000 Da and an average molecular weight from 4000 to 6000 Da, said salt also having a content of organic sulfur from 6.1 to 7.5 weight % (theoretical 6.8%) and a triethanolamine content from 42.6 to 52.1 weight % (theoretical 47.4 weight %). The processes for preparing the heparin salt, eliminating hygroscopicity of said salt, and pharmaceutical compositions for use in local antithrombotic therapy and its uses are also disclosed.
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申请公布号 |
US2005234015(A1) |
申请公布日期 |
2005.10.20 |
申请号 |
US20040024082 |
申请日期 |
2004.12.28 |
申请人 |
DIAZ VICTOR B;MARTINEZ OSCAR E |
发明人 |
DIAZ VICTOR B.;MARTINEZ OSCAR E. |
分类号 |
A61K9/06;A61K9/107;A61K31/727;A61P7/02;A61P9/14;C08B37/00;C08B37/10;(IPC1-7):C08B37/08 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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