发明名称 |
Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and method of use. |
摘要 |
The invention provides methods for preventing or delaying the development of cancer by administering free radical-generating agents to a subject. Representative free radical-generating agents include endoperoxide compounds, such as endoperoxides bearing sesquiterpene compounds such as artemisinin and its analogs, arteflene and its analogs, 1,2,4-trioxanes and 1,2,4,5-tetraoxanes. Intracellular iron concentrations may be enhanced by the administration of iron salts or complexes. |
申请公布号 |
ZA200500023(B) |
申请公布日期 |
2005.10.20 |
申请号 |
ZA20050000023 |
申请日期 |
2005.01.03 |
申请人 |
UNIVERSITY OF WASHINGTON |
发明人 |
LAI, HENRY, C.;SINGH, NARENDRA, P.;TOMIKAZU SASAKI |
分类号 |
A61K38/16;A61K9/14;A61K9/20;A61K9/48;A61K31/00;A61K31/295;A61K31/335;A61K31/357;A61K31/366;A61K31/555;A61K38/00;A61P31/00;A61P31/04;A61P35/00;A61P39/06;C07D493/18;C07K14/79;C07K14/795;C07K14/805 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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