| 摘要 |
Methods, arrays and kits for amplifying and analyzing nucleic acid from compromised biological samples are provided. A method for amplifying both nuclear and mitochondrial DNA from biological samples and for detecting sequences that are characteristic of the sample are disclosed. Samples are fragmented with a restriction enzyme, ligated to an adaptor and adaptor-ligated fragments are amplified. The amplified fragments are analyzed by hybridization to an array comprising probes to detect known variants in mitochondrial DNA. The array may also include probes to detect known polymorphisms in nuclear DNA. The methods are particularly useful for forensic analysis.
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