| 发明名称 |
Regiospecific synthesis of rapamycin 42-ester derivatives |
| 摘要 |
A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent.
|
| 申请公布号 |
US2005234234(A1) |
申请公布日期 |
2005.10.20 |
| 申请号 |
US20050103799 |
申请日期 |
2005.04.12 |
| 申请人 |
WYETH |
发明人 |
GU JIANXIN;CAI PING;RUPPEN MARK E. |
| 分类号 |
C07D491/14;C07D498/18;C12P17/10;C12P17/18;(IPC1-7):C12P17/10 |
主分类号 |
C07D491/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
