NEW THROMBIN INHIBITORS, THEIR PREPARING AND APPLYING

摘要

FIELD: organic chemistry, medicine, pharmacology. ^ SUBSTANCE: invention relates to new inhibitors of thrombin of the formula (I) ^ , ^ method for their preparing, intermediate compounds used for their preparing of the formula (II) ^ and a pharmaceutical composition comprising compounds of the formula (I). Invention provides enhancing effectiveness in inhibition of thrombin. ^ EFFECT: improved preparing method, valuable medicinal properties of compounds. ^ 23 cl, 61 ex