发明名称 |
USE OF A TRIOXOPYRIMIDINE FOR THE TREATMENT AND PREVENTION OF BRONCHIAL INFLAMMATORY DISEASES |
摘要 |
<p>The invention provides the use of a trioxopyrimidine compound having an inhibitory activity against MMP-1, MMP-2, MMP-3, MMP-9 and MMP-14 defined as a) an IC50 value of less than 5 µM for MMP-2, MMP-9 and MMP-14 each; b) a ratio of more than 100 for the IC50 values of MMP-1:MMP-2, MMP-1: MMP-9, MMP-1:MMP-14; and c) a ratio of more than 10 for the IC50 values of MMP-3:MMP-2, MMP-3: MMP-9, MMP-3:MMP-14, for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases.</p> |
申请公布号 |
WO2005097133(A1) |
申请公布日期 |
2005.10.20 |
申请号 |
WO2005EP03345 |
申请日期 |
2005.03.31 |
申请人 |
F. HOFFMANN-LA ROCHE AG;UNIVERSITE DE LIEGE;CATALDO, DIDIER;DELATTRE, LUC;EVRARD, BRIGITTE;FOIDART, JEAN-MICHEL;KRELL, HANS-WILLI |
发明人 |
CATALDO, DIDIER;DELATTRE, LUC;EVRARD, BRIGITTE;FOIDART, JEAN-MICHEL;KRELL, HANS-WILLI |
分类号 |
A61K31/724;A61K31/515;(IPC1-7):A61K31/515;A61P11/00 |
主分类号 |
A61K31/724 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|