发明名称 SUBSTITUTED DIAZA-SPIRO-[5.5]-UNDECANE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS
摘要 <p>This invention concerns substituted diaza-spiro-[5.5]-undecane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, a combined NK1/NK2 antagonistic activity, a combined NK1/NK3 antagonistic activity and a combined NK1/NK2/NK3 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, COPD and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.</p>
申请公布号 WO2005097795(A1) 申请公布日期 2005.10.20
申请号 WO2005EP51508 申请日期 2005.04.04
申请人 JANSSEN PHARMACEUTICA N.V.;JANSSENS, FRANS, EDUARD;SCHOENTJES, BRUNO;COUPA, SOPHIE;PONCELET, ALAIN, PHILIPPE;SIMONNET, YVAN, RENE, FERDINAND 发明人 JANSSENS, FRANS, EDUARD;SCHOENTJES, BRUNO;COUPA, SOPHIE;PONCELET, ALAIN, PHILIPPE;SIMONNET, YVAN, RENE, FERDINAND
分类号 A61K31/438;A61P29/00;C07D471/10;(IPC1-7):C07D471/10 主分类号 A61K31/438
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