Novel aryllimidazole derivatives, preparation and therapeutic used thereof

摘要

The invention concerns compounds of general formula (1) wherein R₁ represents H, alkyl,cycloalkyl or cycloalkylalkyl and R₂ represents H or alkyl; R₃ represents H, alkyl or aralkyl; X represents a bond or a linear or branched alkylene radical (II); Y represents H, cycloalkyl, OR₁₄, SR₁₅, NR₄R₅ or A represents a bond or phenyl; B and B' are independently selected among alkyl, NR₆R₇, SR₈ and carbocyclic aryl orheterocyclic aryl radicals with five or six members optionally substituted; R₄ represents H, alkyl, aryl, cycloalkyl, cycloalkylalkyl, aralkyl, C(O)R₉, C(O)OR₉, -C(O)NHR₉ or -SO₂R₉, or further aryl or aralkyl whereof the aromatic ring is optionally substituted and R₅ represents in particular H or alkyl, or further R, and R₅ form with the nitrogen atom bearing them a non-aromatic hetcrocycle of five to seven members optionally substituted; R₆ represents (in particular) II or alkyl and R₇ represents (in particular) II or alkyl; R₈ represents an alkyl radical optionally substituted; R₉ represents alkyl, haloakyl, cycloalkyl or cycloalkylalkyl, or further one of the aralkyl or aryl or heteroaryl radicals optionally substituted; R₁₄ and R₁₅ independently represent (in particular) alkyl, phenyl or aralkyl. The compounds of general formula (I) can be used as NO synthase inhibitors and as modulators of sodium channels (for treating pains, multiple sclerosis, the central nervous system or the peripheral nervous system and the like).