| 摘要 |
The present invention provides a combination dosing regimen for erythropoiet in (EPO). More particularly, the present dosing regimen includes administration of at least a first dosing segment comprising a first exposure to EPO capabl e of stimulating the production of reticulocytes followed by a second exposure to EPO capable of sustaining the maturation of the reticulocytes into neocytes, and ultimately, red blood cells. Advantageously, the dosing segmen t may be cycled or repeated, any number of times and according to any desired time scheme, in order to provide or maintain any desired total red blood cel l count and/or hemoglobin concentration. Methods of treatment employing the combination dosing regimen, as well as kits are also provided.
|
