摘要 |
PROBLEM TO BE SOLVED: To obtain a medicinal composition not only simultaneously formulating ibuprofen having bad formulation properties with other active ingredients and hard to prepare a stable formulation though the ibuprofen is ingredient effective for cold syndrome, or the like, with an antitussive ingredient and an expectorant ingredient, effectively suppressing a formulation change such as browning, improving the stability and having a high product value. SOLUTION: It is found that the medicinal composition with a suppressed change in color tone with time is obtained by formulating the ibuprofen with dimemorfan or its salt as the antitussive ingredient and potassium cresolsulfonate as the expectorant ingredient. The medicinal composition characterized as suppressing the change in color tone with time is obtained by formulating these ingredients. COPYRIGHT: (C)2006,JPO&NCIPI
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