摘要 |
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections. |
申请人 |
ZYMOGENETICS, INC.;KLUCHER, KEVIN, M.;KINDSVOGEL, WAYNE, R.;SIVAKUMAR, PALLAVUR, V.;HENDERSON, KATHERINE, E. |
发明人 |
KLUCHER, KEVIN, M.;KINDSVOGEL, WAYNE, R.;SIVAKUMAR, PALLAVUR, V.;HENDERSON, KATHERINE, E. |