发明名称 Process for the preparation of dioxane acetic acidesters.
摘要 Process for the preparation of an ester of formula (1), wherein R<1> represents a leaving group, CN, OH or a COOR<5> group, R<3> and R<4> each independently represent a 1-3 C alkyl group, and R<2> and R<6> each independently represent an ester group, wherein the corresponding salt with formula (2), wherein M represents H or an alkali (earth) metal in an inert solvent is contacted with an acid chloride forming agent to form the corresponding acid chloride, and the acid chloride is contacted with an alcohol with formula R<2>OH in the presence of N-methyl-morpholine. Preferably M represents an alkali metal, and R<2> represents an alkyl group, particularly a t.-butyl group. <CHEM> <CHEM>
申请公布号 ZA200409986(B) 申请公布日期 2005.10.19
申请号 ZA20040009986 申请日期 2004.12.09
申请人 ASTRAZENECA UK LIMITED 发明人 HERMANUS CAROLUS CATHERINA KAREL VAN BAKEL;DOMINIQUE MONIQUE CHARLES CALLANT;JACOB HERMANUS MATTHEUS HERO KOOISTRA;PETER JOHANNES DOMINICUS MAAS
分类号 C07B53/00;C07B61/00;C07D319/06 主分类号 C07B53/00
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