PROCESS FOR PREPARING QUINAZOLINE RHO-KINASE INHIBITORS AND INTERMEDIATES THEREOF.

摘要

The present invention relates to methods of producing quinazoline compounds (I) and derivatives thereof which are useful as Rho-kinase Inhibitors or intermediates thereof (3). Rho-kinase inhibitors are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.