11beta-Substituted 19-nor-17-alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring

摘要

This invention relates to new 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring with a long-chain substituent in 11beta-position of general formula II in which R¹¹ is a long-chain alkyl radical that has a nitrogen atom that can be substituted in terminal position with a perfluoroalkyl group. The compounds act in a tissue-selective manner as pure antiestrogens and are suitable for the production of pharmaceutical agents because of these properties.