Composition for controlling fat content and differentiation of adipocytes, useful for treating cellulite, comprising dihydroflavonol, e.g. dihydromyricetin

摘要

Cosmetic and/or pharmaceutical composition (A) for regulating (i) the amount of fat in adipocytes and/or (ii) differentiation of adipocytes, comprises at least one dihydroflavonol (I) and/or its salts or derivatives. Cosmetic and/or pharmaceutical composition (A) for regulating (i) the amount of fat in adipocytes and/or (ii) differentiation of adipocytes contains at least one dihydroflavonol of formula (I) and/or its salts or derivatives. R1, R2, R3, R5H, 1-10C alkyl(carbonyl) or -(CH2)nCH(NH2)COOH; R4, R6R1 or sugar such as glucose, rhamnose, rutinose, galactose or fructose; and n : 0-10. [Image] ACTIVITY : Dermatological; Anorectic. MECHANISM OF ACTION : Lipogenesis inhibitor; Adipogenesis inhibitor; Lipolysis activator; Phosphorylation inhibitor; Phosphatidylinositol-3-kinase inhibitor; Protein kinase B inhibitor. Isolated rat adipocytes were incubated at 37[deg]C in absence or presence of dihydromyricetin (Ia), and after 60 minutes the concentration of glycerol in the culture medium was measured. The concentration (expressed as absorbance at 340 microns) was 0.054 in absence of (Ia) but 0.278, 0.338, 0.478 and 0.631 at (Ia) concentrations of 50, 100, 250 and 500 mu M, respectively.