PREPARATIONS STABILIZED OVER LONG TIME

摘要

Stable G-CSF preparations showing a residual G-CSF ratio of 90 % or more after a long-term storage test at 25 °C for 3 months; showing a residual G-CSF ratio of 90 % or more after a long-term storage test at 40 °C for 2 months; showing a residual G-CSF ratio of 90 % or more after an accelerated test at 50 °C for 1 month; or showing a residual G-CSF ratio of 90 % or more after an accelerated test at 60 °C for 2 weeks; and showing a ratio of the formation of the methionine residue-oxidized derivative of G-CSF of 1 % or less after an accelerated test at 50 °C for 1 month or after an accelerated test at 60 °C for 2 weeks. A method for inhibiting the formation of the methionine residue-oxidized derivative of a physiologically active protein having methionine residues characterized by adding methionine to a composition containing this protein.