The invention provides methods of screening test compounds for their ability to reduce retention of atherogenic lipoproteins in atherogenesis by measuring their activity as a modulator of the binding affinity of CEL (Carboxyl Ester Lipase) to various receptors. The invention further provides methods for the use of active modulators of the binding affinity of CEL to receptors for the prevention and treatment of atherosclerosis.
申请公布号
WO2005095986(A2)
申请公布日期
2005.10.13
申请号
WO2005IB51095
申请日期
2005.04.01
申请人
AREXIS AB;BJURSELL, KARL GUNNAR;NILSSON, JEANETTE ANNIKA;ELLMARK, SARA
发明人
BJURSELL, KARL GUNNAR;NILSSON, JEANETTE ANNIKA;ELLMARK, SARA