发明名称 |
METHOD OF TREATING SOLID TUMORS AND LEUKEMIAS USING COMBINATION THERAPY OF VITAMIN D AND ANTI-METABOLIC NUCLEOSIDE ANALOGS |
摘要 |
The present invention relates to a method of inhibiting solid tumor cell or leukemia cell proliferation by first administering to a solid tumor cell or leukemia cell either vitamin D or a derivative thereof and subsequently administering at least one anti-metabolic nucleoside analog to the solid tumor cell or the leukemia cell. Also disclosed is a method of treating a cancerous condition. Methods of down regulating a p-AKt survival signaling pathway and modulating activity of a pro-apoptotic caspases is also disclosed. |
申请公布号 |
WO2005094358(A2) |
申请公布日期 |
2005.10.13 |
申请号 |
WO2005US10655 |
申请日期 |
2005.03.29 |
申请人 |
ROSWELL PARK CANCER INSTITUTE |
发明人 |
JOHNSON, CANDACE, S.;TRUMP, DONALD, L. |
分类号 |
A61K31/59;A61K31/7072;A61K31/7076 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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