NEW FOXP1 PROTEINS

摘要

The present invention is based on the discovery that low molecular weight forms of the FOXP1 protein are expressed at high levels in activated B-cells and in a certain subtype of diffuse large B-cell lymphoma (DLBCL). The invention relates to a novel FOXP1 splice variant, the protein encoded by the splice variant and methods of detection and diagnosis based upon detecting the novel splice variant. Also provided are reagents including siRNA molecules which can down regulate the transcript of the splice variant, as well as methods of treatment of diseases associated with an activated B-cell state and pharmaceutical compositions.