发明名称 |
CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 INDUCES ISCHEMIC VENTRICULAR ARRHYTHMIAS AND DECREASES INFARCTION SIZE |
摘要 |
A method for evaluating a compound to determine the relative or absolute therapeutic capability of a compound to pharmacologically inhibit ischemia induced activation of iPLA2beta in an intact myocardium which comprises treating intact myocardium with a compound, inducing ischemia in the myocardium tissue and determining if there has been a change in expression of iPLA2beta, its activity or in the iPLA2beta regulating network and determining if there has been a change then that the compound is an anti-arrhythmia or myocardial salvage drug. |
申请公布号 |
WO2004054436(A3) |
申请公布日期 |
2005.10.13 |
申请号 |
WO2003US40301 |
申请日期 |
2003.12.15 |
申请人 |
WASHINGTON UNIVERSITY IN ST. LOUIS;GROSS, RICHARD, W. |
发明人 |
GROSS, RICHARD, W. |
分类号 |
A01K67/027;A61B;C07H21/04;C12N9/20;C12Q1/34;C12Q1/44;G01N33/50;G01N33/92 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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