DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH MIXED LINEAGE KINASE 4 BETA (MLK4 BETA)

摘要

The invention provides a human MLK4 beta which is associated with cardiovascular diseases, dermatological diseases, endocrinological disease, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological disease, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MLK4 beta as well as pharmaceutical compositions comprising such compounds.