发明名称 |
Drugs for improving the prognosis of brain injury and a method of screening the same |
摘要 |
There are provided a compound for treatment or prevention of brain injury caused by diseases such as cerebrovascular disorder, brain degenerative disease and demyelinating disease and a method for screening the same. Brain injury in which prostaglandin D<SUB>2 </SUB>is participated is treated or prevented by inhibition of hematopoietic prostaglandin D synthase induced in microglia cell or macrophage of brain injury area by diseases such as cerebrovascular disorder, brain degenerative disease or demyelinating disease or by inhibition of activation of prostaglandin D receptor expressed in astroglia cell around the injured area. There is also provided a method of testing those pharmaceutical substances using a transgenic mouse in which human hematopoietic prostaglandin D synthase is expressed in large amounts.
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申请公布号 |
US2005227984(A1) |
申请公布日期 |
2005.10.13 |
申请号 |
US20050139530 |
申请日期 |
2005.05.31 |
申请人 |
URADE YOSHIHIRO;EGUCHI NAOMI;ARITAKE KOSUKE;SATO YO;KADOYAMA KEIICHI;TANIIKE MASAKO |
发明人 |
URADE YOSHIHIRO;EGUCHI NAOMI;ARITAKE KOSUKE;SATO YO;KADOYAMA KEIICHI;TANIIKE MASAKO |
分类号 |
A61K31/381;A61K31/454;A61K31/53;A61K45/06;A61P25/00;A61P43/00;C07D333/68;G01N33/50;G01N33/68;G01N33/88;(IPC1-7):A61K31/558 |
主分类号 |
A61K31/381 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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