NOVEL GENES FROM A BIOSYNTHESIS GENE CLUSTER FOR AMINOGLYCOSIDE ANTIBIOTIC SYNTHESIS AND THE THUS OBTAINED NOVEL AMINOGLYCOSIDE ANTIBIOTICS

摘要

The invention relates to novel genes obtainable from aminoglycoside-producing microorganisms, to novel gene clusters formed from the novel and/or known genes of said microorganisms, to the expression products of the genes, the transport vehicles thereof or of the gene clusters and to transformed cells containing said genes or gene clusters. Said invention also relates to methods for biologically producing aminoglycosides, methods for combinatory synthesis of aminoglycoside derivatives, to novel aminoglycosides, to the use thereof and to pharmaceutical compositions containing said aminoglycosides.