发明名称 |
PREPARATION OF P-CHIROGENIC PHOSPHOLANES AND THEIR USE IN ASYMETRIC SYNTHESIS |
摘要 |
<p>Materials and methods for preparing P-chirogenic monophospholanes and bisphospholanes are disclosed. The methods employ stereoselective cyclization to generate the phospholane rings followed by pyramidal inversion to access a variety of P-chirogenic phospholanes. When bound to transition metals such as rhodium, the disclosed P-chirogenic phospholanes may be used as catalysts in asymmetric synthesis of valuable pharmaceutical chemical entities, including pregabalin.</p> |
申请公布号 |
WO2005095424(A1) |
申请公布日期 |
2005.10.13 |
申请号 |
WO2005IB00768 |
申请日期 |
2005.03.23 |
申请人 |
WARNER-LAMBERT COMPANY LLC;HOGE, GARETT, STEWART |
发明人 |
HOGE, GARETT, STEWART |
分类号 |
C07D327/10;C07F9/02;C07F9/6568;C07F15/00;(IPC1-7):C07F9/656 |
主分类号 |
C07D327/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|