| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for simply and efficiently producing optically active erythro-3-cyclohexylserine being an intermediate for a medicine such as an intermediate for a medicine (WOO1/40227) known to be useful as an anti-HIV medicine or its Boc compound. <P>SOLUTION: The method for producing an N-acyl-D-erythro-3-substituted serine represented by general formula (2) (R<SB>1</SB>is a 1-10C alkanoyl group, a benzoyl group, a 1-5C alkanoyl group which is substituted with a halogen atom or a benzoyl group which is substituted with a halogen atom; R<SB>2</SB>is a phenyl group or a cyclohexyl group) comprises asymmetrically hydrolyzing an N-acyl compound of a DL-erythro-3-substituted serine represented by general formula (1) with L-aminoacylase or a substance obtained by immobilizing the enzyme. <P>COPYRIGHT: (C)2006,JPO&NCIPI |
