| 发明名称 |
DNA damage repair inhibitors for the treatment of cancer |
| 摘要 |
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
|
| 申请公布号 |
US2005227919(A1) |
申请公布日期 |
2005.10.13 |
| 申请号 |
US20040001474 |
申请日期 |
2004.11.30 |
| 申请人 |
THE INSTITUTE OF CANCER RESEARCH |
发明人 |
ASHWORTH ALAN;JACKSON STEPHEN;MARTIN NIALL;SMITH GRAEME |
| 分类号 |
A61K31/00;A61K31/366;A61K31/405;A61K31/4184;A61K31/4706;A61K31/473;A61K31/502;A61K31/517;A61K31/522;A61K31/675;A61K38/54;A61K48/00;(IPC1-7):A61K38/54;A61K31/470;A61K31/418 |
主分类号 |
A61K31/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
