发明名称 Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
摘要 Process for the synthesis of ivabradine of formula (I): addition salts with a pharmaceutically acceptable acid and hydrates thereof. alpha crystalline form of ivabradine hydrochloride. Medicinal products containing the a crystalline form of ivabradine hydrochloride, which are useful as bradycardics.
申请公布号 US2005228177(A1) 申请公布日期 2005.10.13
申请号 US20050057492 申请日期 2005.02.14
申请人 LERESTIF JEAN-MICHEL;LECOUVE JEAN-PIERRE;SOUVIE JEAN-CLAUDE;BRIGOT DANIEL;HORVATH STEPHANE;AUGUSTE MARIE-NOELLE;DAMIEN GERARD 发明人 LERESTIF JEAN-MICHEL;LECOUVE JEAN-PIERRE;SOUVIE JEAN-CLAUDE;BRIGOT DANIEL;HORVATH STEPHANE;AUGUSTE MARIE-NOELLE;DAMIEN GERARD
分类号 A61K31/55;A61P9/00;A61P9/04;A61P9/06;A61P9/10;C07D223/16;(IPC1-7):C07D223/16 主分类号 A61K31/55
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