发明名称 |
HYDRAZIDE-CONTAINING CFTR INHIBITOR COMPOUNDS AND USES THEREOF |
摘要 |
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a hydrazide-containing compound to a non-human animal in an amount sufficient to inhibit CFTR. |
申请公布号 |
WO2005094374(A2) |
申请公布日期 |
2005.10.13 |
申请号 |
WO2005US10787 |
申请日期 |
2005.03.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;VERKMAN, ALAN;SONAWANE, NITIN DATTATRAYA;MUANPRASAT, CHATCHAI |
发明人 |
VERKMAN, ALAN;SONAWANE, NITIN DATTATRAYA;MUANPRASAT, CHATCHAI |
分类号 |
A61K31/165;A61K31/195;A61K31/47;A61K31/7012 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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