| 摘要 |
Methods of treating nervous disorders are provided comprising administering into the circulatory system of a patient in need of such treatment, a neuroactive fusion molecule comprising a therapeutic moiety and a moiety capable of trans-synaptically carrying the therapeutic moiety to a selected neuron across the blood-brain barrier or the blood-nerve barrier. Large therapeutic proteins may be transported by the methods of this invention. The therapeutic moiety can be targeted to neurons in the central nervous system as well as in the peripheral nervous system, e.g., to nerves involved in sensation such as nerves of pain systems, the enteric nervous system, the autonomic nervous system, and others. Conventional devices such as pills, i.v. injection means, suppositories, and other means known to the art for delivery into the circulatory system can be used. |
