发明名称 |
METHODS FOR IDENTIFYING DRUG NON-TARGET PROTEINS |
摘要 |
A capture compound and a method of identifying drug target non-target proteins in a mixture of proteins is provided, comprising the steps of interacting the mixture with a capture compound of the formula Q-Z-( Xm)-Yn, wherein Z is a trivalent moiety for presenting X, Y and Q; moiety X is selected to covalently bind to proteins; moiety Y is a pharmaceutical drug, drug fragment, drug metabolite, prodrug, enzyme substrate, enzyme inhibitor, transition-state analogue or a ligand to a receptor; Q is a sorting function selected to permit physical arraying or other addressable separation method suitable for analysis, Q comprises a biotin moiety, a (His) 6 moiety, a BODIPY moiety (4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene), an oligonucleotide or PNA (peptide nucleic acid), an antibody, an immunotoxin conjugate, an adhesive peptide, a lectin, an activated dextran or a peptide; and analyzing the captured proteins to identify drug target or drug non-target. |
申请公布号 |
EP1583972(A2) |
申请公布日期 |
2005.10.12 |
申请号 |
EP20040702919 |
申请日期 |
2004.01.16 |
申请人 |
HK PHARMACEUTICALS, INC.;KOESTER, HUBERT |
发明人 |
KOESTER, HUBERT;LITTLE, DANIEL, PAUL;SIDDIQI, SUHAIB, MAHMOOD;GREALISH, MATTHEW, PETER;MARAPPAN, SUBRAMANIAN;HASSMAN III, CHESTER, FREDERICK;YIP, PING |
分类号 |
C07C69/76;C07C69/96;C07D207/40;C07D207/404;C07D207/46;C07D209/48;C07D211/60;C07D211/78;C07D213/79;C07D215/48;C07D239/54;C07D239/545;C07D241/44;C07D261/12;C07D271/06;C07D271/07;C07D303/14;C07D303/16;C07D317/36;C07D401/12;C07D405/10;C07D405/12;C07D495/04;C07D498/18;C07D519/00;G01N33/68;(IPC1-7):G01N33/68 |
主分类号 |
C07C69/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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