发明名称 |
COMPOSITION FOR INTRACELLULAR TRANSPORT OF BIOLOGICAL PARTICLES OR MACROMOLECULES |
摘要 |
Preparing a composition (A) for introducing, into a living cell, a cargo (B) comprising a macromolecule or a molecular assembly of largest dimension not over 1 micron and having one or more hydrophobic domains (HD) on its surface, is new. Preparing a composition (A) for introducing, into a living cell, a cargo (B) consisting of a macromolecule or a molecular assembly of largest dimension not over 1 micron and having one or more hydrophobic domains (HD) on its surface. The method comprises adsorption, on HD, of at least one transducer peptide (I), excluding those of 16-30 amino acids (aa) that contain an HD of 3-5 Trp residues (including at least one Trp-Trp pair), alternating with Glu or Thr residues, and a hydrophilic domain of 4 or 5 consecutive basic residues. An Independent claim is also included for (A) prepared by the new process. |
申请公布号 |
EP1583560(A1) |
申请公布日期 |
2005.10.12 |
申请号 |
EP20030815710 |
申请日期 |
2003.12.31 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);ECOLE NORMALE SUPERIEURE |
发明人 |
PROCHIANTZ, ALAIN;DUPONT, EDMOND;JOLIOT, ALAIN;TREMBLEAU, ALAIN;VOLOVITCH, MICHEL |
分类号 |
A61K47/42;A61K48/00;C12N7/01 |
主分类号 |
A61K47/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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