发明名称 |
MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO |
摘要 |
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. |
申请公布号 |
EP1482928(A4) |
申请公布日期 |
2005.10.12 |
申请号 |
EP20020763383 |
申请日期 |
2002.07.29 |
申请人 |
CURIS, INC. |
发明人 |
RUBIN, LEE;GUICHERIT, OIVIN, M.;PRICE, STEPHEN;BOYD, EDWARD A. |
分类号 |
C07D235/18;A61K8/49;A61K31/395;A61K31/4184;A61K31/423;A61K31/428;A61P1/16;A61P7/00;A61P11/00;A61P15/00;A61P17/00;A61P17/14;A61P19/00;A61P21/00;A61P25/00;A61P35/00;C07D405/12;C12N5/02;C12N15/12 |
主分类号 |
C07D235/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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