发明名称 |
SIGMA RECEPTOR-DEFICIENT, MUTANT, NON-HUMAN MAMMALS AND APPLICATIONS THEREOF |
摘要 |
The genome of the non-human mutant mammal, deficient in an endogenous Sigma receptor, contains a mutation that comprises a disruption in an endogenous Sigma receptor gene, wherein said gene disruption gives rise to a mutant lacking detectable levels of endogenous Sigma receptor. The mutant may be used as a control animal for in vivo tests, as well as a source of cells that can be used in in vitro tests. Mutants deficient in the Sigma-1 receptor can be used as models for in vivo study of disorders of the central nervous system, memory alterations, stress conditions and drug addictions, analgesia processes and neuroprotection. Mutants deficient in the Sigma-2 receptor can be used to study diagnostic or therapeutic tools to fight cancer and/or degenerative processes and/or to design compounds capable of preventing, reducing or alleviating the secondary pathology associated with administration of neuroleptic agents.
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申请公布号 |
EP1584232(A1) |
申请公布日期 |
2005.10.12 |
申请号 |
EP20030778357 |
申请日期 |
2003.12.09 |
申请人 |
LABORATORIOS DEL DR. ESTEVE, S.A. |
发明人 |
ZAMANILLO CASTANEDO, DANIEL;MONTOLIU JOSE, LLUIS;LANGA VIVES, FRANCINA;LAVADO JUDEZ, ALFONSO, JAVIER;TOVAR HERRADOR, VICTORIA, EUGENIA |
分类号 |
C07K14/705;C12N15/12;C12N15/85;C12N15/90;(IPC1-7):A01K67/027;C12N5/10;C12N15/63 |
主分类号 |
C07K14/705 |
代理机构 |
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